Advantage Multi Topical Solution for Large Dogs 88.1-110 lbs, Brown

Advantage Multi Topical Solution for Large Dogs 88.1-110 lbs

Monthly Protection from Fleas, Heartworms & More

Advantage Multi Topical Solution for Dogs 88.1–110 lbs is a veterinarian-recommended, once-monthly topical treatment formulated to protect large dogs from a broad spectrum of internal and external parasites. This all-in-one topical formula combines imidacloprid and moxidectin, two powerful active ingredients that work synergistically to eliminate fleas, prevent heartworm disease, and treat/control intestinal worms like roundworms, hookworms, and whipworms.

Designed for large breed dogs between 88.1 and 110 lbs, this waterproof solution is ideal for multi-parasite protection with just one easy monthly application.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Also Available in Other Weight Ranges

Looking for the right dose of Advantage Multi for your dog’s specific weight? Explore the full range of vet-recommended flea, heartworm, and worm protection tailored to different sizes:

• Advantage Multi for Dogs 3-9 lbs (Green) – For extra-small breeds and puppies 
• Advantage Multi for Dogs 9.1-20 lbs (Teal) – Perfect for small breeds
• Advantage Multi for Dogs 20.1-55 lbs (Red) – Ideal for medium-sized dogs
• Advantage Multi for Dogs 55.1-88 lbs (Blue) – Designed for large dogs
• Advantage Multi for Dogs 88.1-110 lbs (Brown) – For extra-large breeds (you are viewing this product)

Each formula delivers broad-spectrum parasite protection, combining Imidacloprid and Moxidectin in weight-specific doses for optimal safety and effectiveness.

What Are the Benefits of Advantage Multi Topical Solution for Dogs 88.1-110 lbs?

Advantage Multi is more than just a flea treatment—it's a total parasite defense system. Here’s how it outperforms traditional flea-only options:

Broad-Spectrum Protection

• Kills adult fleas on contact (no need for them to bite)

• Prevents heartworm disease when applied monthly

• Treats and controls roundworms, hookworms, whipworms

• Effective against sarcoptic mange

Fast-Acting & Long-Lasting

• Begins killing fleas within 4 hours

• Monthly dosage provides 30 days of continuous protection

Mess-Free Topical Application

• Easy to apply, no pills or injections

• Waterproof after 24 hours—safe for bathing and swimming

Veterinary-Approved Formula

• Contains imidacloprid and moxidectin, both clinically proven for parasite control

• Prescription-only quality now accessible through HardyPaw

One Solution, Many Problems Solved

• Ideal for households dealing with multiple parasites

• Reduces vet visits and minimizes need for multiple medications

When Should I Start Using Advantage Multi on My Dog?

Parasite protection is most effective when it’s proactive—not reactive. The best time to start using Advantage Multi is before your dog becomes vulnerable.

Ideal Starting Time:

• Begin use at 7 weeks of age, if your dog is at least 88.1 lbs

• Use year-round to protect from heartworms, which are transmitted by mosquitoes—even indoors

• Monthly application ensures continuous, cumulative protection

⏰ Pro Tip: Set calendar reminders or enroll in auto-ship to avoid missing a dose, which can leave your dog exposed to serious health risks like heartworm disease.

How Do You Use Advantage Multi for Large Dogs?

Directions for Use:

• Apply topically once a month directly to the skin.

• Part the hair at the base of your dog’s neck (between the shoulder blades).

• Squeeze entire contents of tube on a single spot.

• Do not massage in or allow your dog to lick the application site.

• Ensure the application site remains dry for 24 hours.

Recommended for dogs weighing between 88.1 and 110 lbs. Do not use on cats or other animals.

How to Apply Advantage Multi Topical Solution for Dogs 88.1–110 lbs Correctly

Applying Advantage Multi Topical Solution the right way ensures your large dog receives maximum parasite protection. Follow these step-by-step instructions for safe, mess-free use:

Step 1: Preparation

• Remove one tube from the package.
• Hold the tube upright and pull off the cap.
• Flip the cap over and use the other end to puncture the seal on the tip of the tube.

Step 2: Application

• With your dog standing, part the fur at the base of the neck (between the shoulder blades) until skin is clearly visible.
• Place the tip of the tube directly onto the skin, not the fur.
• Squeeze the tube gently to apply the entire contents in a single spot.
• Avoid applying an excessive amount to one location to prevent runoff or irritation.

Step 3: Post-Application Care

• Ensure the area stays dry for at least 24 hours—no bathing or swimming.
• Prevent your dog from licking the application site until it is fully dry.
• Monitor your pet for a few minutes to ensure they’re comfortable and not irritated by the application.

Reminder: Apply once a month on the same date to maintain continuous protection against fleas, heartworms, and intestinal parasites.

💡 Pro Tip: Use gloves during application and always wash your hands thoroughly afterward.

What Ingredients Are in Advantage Multi Topical Solution?

These two ingredients work in tandem to offer multi-layered parasite protection internally and externally.

What Makes Advantage Multi Different From Other Flea and Heartworm Treatments?

When it comes to protecting your large dog, not all parasite treatments are created equal. Advantage Multi Topical Solution stands out by offering a multi-spectrum defense against both external and internal parasites in a single, once-a-month topical dose.

Key Differentiators:

• Flea & worm protection in one—no need for separate products

• Contains moxidectin, which not only prevents heartworms but also treats intestinal worms like hookworms, roundworms, and whipworms

• Also treats sarcoptic mange, which many competitors don’t cover

• Topical application makes it ideal for dogs who dislike pills

• Approved by veterinarians and trusted by pet parents for over a decade

Unlike oral flea-only pills or single-focus treatments, Advantage Multi is a complete parasite protection plan for dogs between 88.1 and 110 lbs.

What Are the Side Effects of Advantage Multi for Large Dogs?

While Advantage Multi is generally safe, some dogs may experience:

• Temporary itching or redness at application site

• Gastrointestinal upset (vomiting or diarrhea)

• Lethargy or changes in behavior in rare cases

Monitor your dog after application. If side effects persist or worsen, contact your veterinarian promptly.

Are There Any Warnings or Precautions?

• For external use only. Do not allow ingestion.

• Do not use on puppies under 7 weeks old or under 88.1 lbs for this variant.

• Keep away from children and other pets during and after application.

• Use caution in heartworm-positive dogs—consult your vet prior to application.

• Not intended for use in breeding, pregnant, or lactating dogs unless prescribed.

What’s in the Box of Advantage Multi for Large Dogs 88.1 and 110 lbs?

Each package contains 6 single-dose applicators, each designed for one-month use. Protects your dog for 6 months total.

Shipping & Returns 

Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Advantage Multi for Dogs 88.1–110 lbs FAQs 

What is Advantage Multi Topical Solution used for?

Advantage Multi is used to prevent heartworms, kill adult fleas, and treat/control roundworms, hookworms, whipworms, and sarcoptic mange in dogs.

How quickly does Advantage Multi start working?

It begins killing adult fleas within 4 hours of application, and continues to protect against parasites for a full 30 days.

Is Advantage Multi safe for dogs with sensitive skin?

Yes, it’s generally well tolerated, but dogs with sensitive skin may experience mild irritation at the application site. Always monitor after first use.

Can I bathe my dog after applying Advantage Multi?

Yes, but wait at least 24 hours after application to allow the solution to fully absorb and become waterproof.

What if I miss a dose of Advantage Multi for large dogs?

Apply as soon as possible. If it’s close to the next scheduled dose, skip the missed dose and continue with the regular monthly schedule. Do not double up doses.

Clinical Research

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fc1a42b-6576-4890-aa0c-5c0eb903c85a

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/804